Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3051 |
| PDBID: | 6VRQ |
| Chains: | HL_B |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.57 |
| Reference: | 10.1016/j.celrep.2021.109084 |
| Antibody | |
| Antibody: | anti-idiotype iv12 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | gl12A21 Fab light chain |
| Antigen mutation: | No |
| Durg Target: | P01834 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6VRQ_H|Chain A[auth H]|iv12 Fab Heavy Chain|Mus musculus (10090) QVQLQQSGAELARPGASVKLPCKASGYTFTNYGLIWVKQRSGQGLEWIGEIYPRSGNTYYNEKFKGKATLTADKSSSTAYMELRSLASEDSAVYFCAKKFMPTGFFDYWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: L
Mutation: NULL
| >6VRQ_L|Chain B[auth L]|iv12 Fab Light Chain|Mus musculus (10090) DIVMTQSHKSMSTSIGDRVSITCKASQDVSIAVAWYQQNPGQSPKLLIFSASYRYTGVPDRFTGSGSGTDFTITITSVQAEDLAVYYCQQHHSNPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >6VRQ_B|Chain D[auth B]|gl12A21 Fab Light Chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCAVLEFFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ARG53 SER54 B: ASN31 TYR32 ASP50 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
