Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3050 |
| PDBID: | 6VRQ |
| Chains: | HL_A |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.57 |
| Reference: | 10.1016/j.celrep.2021.109084 |
| Antibody | |
| Antibody: | anti-idiotype iv12 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | gl12A21 Fab heavy chain |
| Antigen mutation: | No |
| Durg Target: | Q6PYX1; P23083; P01857; P01859; P01861; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6VRQ_H|Chain A[auth H]|iv12 Fab Heavy Chain|Mus musculus (10090) QVQLQQSGAELARPGASVKLPCKASGYTFTNYGLIWVKQRSGQGLEWIGEIYPRSGNTYYNEKFKGKATLTADKSSSTAYMELRSLASEDSAVYFCAKKFMPTGFFDYWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: L
Mutation: NULL
| >6VRQ_L|Chain B[auth L]|iv12 Fab Light Chain|Mus musculus (10090) DIVMTQSHKSMSTSIGDRVSITCKASQDVSIAVAWYQQNPGQSPKLLIFSASYRYTGVPDRFTGSGSGTDFTITITSVQAEDLAVYYCQQHHSNPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >6VRQ_A|Chain C[auth A]|gl12A21 Fab Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARDGSGDDTSWHLHPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR30 ASN31 TYR32 GLY33 ARG53 SER54 ASN56 TYR58 LYS95 MET97 PRO98 THR99 L: SER30 ILE31 ALA32 PHE49 SER50 TYR53 HIS91 HIS92 A: THR28 THR30 GLY31 TYR32 TYR33 PRO52 ASN53 SER54 GLY56 ARG71 THR73 SER74 ASP95 GLY96 SER97 GLY98 ASP99 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
