Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3039 |
| PDBID: | 6VO0 |
| Chains: | GJ_C |
| Organism: | Oryctolagus cuniculus, Human immunodeficiency virus 1 |
| Method: | EM |
| Resolution (Å): | 3.52 |
| Reference: | 10.1126/sciadv.aba0512 |
| Antibody | |
| Antibody: | 43A2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 BG505 SOSIP.v5.2 gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >6VO0_G|Chain B[auth G], F[auth H], J[auth I]|43A2 heavy chain|Oryctolagus cuniculus (9986) RQLVESGGGLVQPEGSLTLTCKASGFSFSRSQYMCWVRQAPGKGLEWITCVYPDDDTPYYATWAKGRFTISKTSSTTVTLRLTSLTEADTATYFCARTSGFGGYSYAAHGVDLWGPGTLV |
Light Chain: J
Mutation: NULL
| >6VO0_J|Chain A[auth J], E[auth K], I[auth L]|43A2 light chain|Oryctolagus cuniculus (9986) DIVMTQTPASVSEPVGGTVTIKCQASHNIRSYLSWYQQKVGQPPKRLIYETSNLASGVPSRFAGSGSGTEFTLTISDLECADAATYYCQSNFGLSDSRTYNFGGGTEVVVKGD |
Antigen
Chain: C
Mutation: NULL
| >6VO0_C|Chain C[auth A], G[auth C], K[auth D]|Envelope glycoprotein gp120|Human immunodeficiency virus 1 (11676) AENLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHCCVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition J: ARG30 LEU94 G: ARG31 TYR34 ASP53 ASP54 THR56 TYR58 GLY99 C: ASN133 THR135 ASN136 ASN137 ILE138 THR139 ASP140 ASP141 ARG151 ASP325 ARG327 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
