Details
Structure visualisation
Entry information
Sequence information
Antibody
Heavy Chain: Z
Mutation: NULL
| >6VMK_Z|Chain AA[auth B], C[auth E], DA[auth H], F[auth K], GA[auth M], I[auth P], JA[auth S], L[auth V], MA[auth Z], O[auth c], PA[auth f], R[auth i], SA[auth l], U[auth o], VA[auth r], X[auth u]|Fab Y49R heavy chain|Homo sapiens (9606) EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGEINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT |
Light Chain: Y
Mutation: NULL
| >6VMK_Y|Chain B[auth A], CA[auth D], E[auth G], FA[auth J], H[auth L], IA[auth O], K[auth R], LA[auth U], N[auth Y], OA[auth b], Q[auth e], RA[auth h], T[auth k], UA[auth n], W[auth q], Z[auth t]|Fab Y49R light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIRSASSRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: a
Mutation: NULL
| >6VMK_a|Chain A[auth C], BA[auth F], D[auth I], EA[auth N], G[auth Q], HA[auth T], J[auth W], KA[auth X], M[auth a], NA[auth d], P[auth g], QA[auth j], S[auth m], TA[auth p], V[auth s], Y[auth v]|Complement factor D|Homo sapiens (9606) ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Y: ASP30 ASP32 ALA34 PHE36 ARG49 SER50 TYR55 GLN89 TYR91 ASN92 TYR94 LEU96 Z: THR28 THR30 SER31 TYR32 TYR33 TYR35 GLU50 ASN52 PRO53 THR54 ARG98 GLU99 GLY100 GLY101 a: PRO132 ASP164 ARG165 ALA166 THR167 ASN169 THR170 ASP173 GLY174 ILE176 GLU178 LYS223 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
