Details
Structure visualisation
Entry information
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6VMJ_B|Chain B, D[auth F], F[auth J], H[auth M]|Fab20D12 heavy chain|Homo sapiens (9606) EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMYWVRQAPGQGLEWIGEINPTSGGTNFNEKFKSRATLTVDTSTSTAYLELSSLRSEDTAVYYCAREGGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT |
Light Chain: A
Mutation: NULL
| >6VMJ_A|Chain A, C[auth E], E[auth I], G[auth L]|Fab20D12 Light Chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCKASQNVDTDVAWFQQKPGKAPKGLIYSASSRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: Z
Mutation: NULL
| >6VMJ_Z|Chain I[auth W], J[auth X], K[auth Y], L[auth Z]|Complement factor D|Homo sapiens (9606) ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASP30 THR31 ASP32 ALA34 PHE36 TYR49 TYR55 GLN89 TYR91 ASN92 TYR94 LEU96 B: THR28 THR30 SER31 TYR32 TYR33 TYR35 GLU50 PRO52 THR53 ARG94 GLU95 GLY96 GLY97 Z: PRO132 ASP164 ARG165 ALA166 THR167 ASN169 THR170 ASP173 GLY174 ILE176 THR177 GLU178 LYS223 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
