Details
Structure visualisation
Entry information
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1ADQ_H|Chain C[auth H]|IGM-LAMBDA RF-AN FAB (HEAVY CHAIN)|Homo sapiens (9606) EVQLVESGGGLVQPGRSLRLSCVTSGFTFDDYAMHWVRQSPGKGLEWVSGISWNTGTIIYADSVKGRFIISRDNAKNSLYLQMNSLRVEDTALYYCAKTRSYVVAAEYYFHYWGQGILVTVSSGSASAPTLFPLVSCENSNPSSTVAVGCLAQDFLPDSITFSWKYKNNSDISSTRGFPSVLRGGKYAATSQVLLPSKDVMQGTNEHVVCKVQHPNGNKEKDVPL |
Light Chain: L
Mutation: NULL
| >1ADQ_L|Chain B[auth L]|IGM-LAMBDA RF-AN FAB (LIGHT CHAIN)|Homo sapiens (9606) YVLTQPPSVSVAPGQTARITCGGNNIGSKSVHWYQQKPGQAPVLVVYDDSDRPPGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVWDSSSDHAVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >1ADQ_A|Chain A|IGG4 REA FC|Homo sapiens (9606) PSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPQVQFNWYVDGVQVHNAKTKPREQQFNSTYRVVSVLTVLHQNWLDGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: SER32 TYR49 ASP50 ASP53 PRO56 GLY57 H: GLU1 VAL2 GLY26 THR28 ASP31 TYR32 TRP52 ARG96 SER97 TYR98 VAL99 TYR102 A: LEU251 MET252 ILE253 SER254 ARG255 THR256 GLN311 GLU382 SER383 ASN384 GLY385 GLN386 VAL422 SER424 MET428 HIS433 ASN434 HIS435 TYR436 THR437 GLN438 SER440 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
