Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2964 |
| PDBID: | 6UYG |
| Chains: | HL_E |
| Organism: | Recombinant Hepatitis C virus HK6a/JFH-1, Homo sapiens, Streptococcus sp. |
| Method: | XRD |
| Resolution (Å): | 3.38 |
| Reference: | 10.1126/sciadv.aaz6225 |
| Antibody | |
| Antibody: | AR3A Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hepatitis C Virus Envelope glycoprotein E2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6UYG_H|Chain B[auth H]|Fab AR3A heavy chain|Homo sapiens (9606) VQLLEQSGAEVKTPGSSVRVSCRPPGGNFNSYSINWVRQAPGHGLEWVGTFIPMFGTSKYAQKFQGRVTITADGSSGTAYMDLNSLRSDDTAFYYCVRPETPRYCSGGFCYGEFDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCGS |
Light Chain: L
Mutation: NULL
| >6UYG_L|Chain C[auth L]|Fab AR3A light chain|Homo sapiens (9606) ELTLTQSPGTLSLSPGKRATLSCRASQSVSGSYLAWYQQKPGQAPRLLIYGASNRATGIPHRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPTFGQGTRVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >6UYG_E|Chain A[auth E]|Envelope glycoprotein E2|Recombinant Hepatitis C virus HK6a/JFH-1 (595609) QLINTNGSWHINRTALNCNDSLQTGFITSLFYAKNVDSSGCPERMAACGSSGCWHYAPRPCDVVSARTVCGPVYCFTPSPVVVGTTDKLGIPTYNWGENETDVFMLESLRPPTGGWFGCTWMNSTGFTKTCGAPPGGPTDGGSGPWITPRCLVDYPYRLWHYPCTVNFTLHKVRMFVGGIEHRFDAACN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: ASN30 SER31 TYR32 MET53 PHE54 THR56 GLU96 THR97 PRO98 ARG99 L: TYR32 TYR49 GLY50 ASN53 E: ILE422 THR425 LEU427 ASN428 CYS429 ASN430 ASP431 GLN434 GLY436 ILE438 THR439 LEU441 PHE442 TYR443 LYS445 ARG500 TRP529 GLU531 TYR613 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
