Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 296 |
| PDBID: | 2NR6 |
| Chains: | FE_B |
| Organism: | Blattella germanica, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.81 |
| Reference: | 10.1074/jbc.M800937200 |
| Antibody | |
| Antibody: | 7C11 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Aspartic protease Bla g 2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: F
Mutation: NULL
| >2NR6_F|Chain D, F|Antibody heavy chain|Mus musculus (10090) EIQLQQSGAELVKPGASVKLSCTASGFNIKDTYIHWVKQRPEQGLEWIGRIDPANGNTRYGPKFLGKATITADTSSNTAYLHLNSLTSEDTAVYFCARWVRQMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKI |
Light Chain: E
Mutation: NULL
| >2NR6_E|Chain C, E|Antibody light chain|Mus musculus (10090) DIVMTQSHKFMSTSVGDRVSITCKASQIVSTAVAWYQQKPGQSPKLLIYSASYRYTGVPDRFTGSGSGTDFTFTISSVQAEDLAVYYCQQHYNSPQTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR |
Antigen
Chain: B
Mutation: NULL
| >2NR6_B|Chain A, B|Aspartic protease Bla g 2|Blattella germanica (6973) GASIVPLYKLVHVFINTQYAGITKIGNQNFLTVFDSTSCNVVVASQECVGGACVCPNLQKYEKLKPKYISDGNVQVKFFDTGSAVGRGIEDSLTISQLTTSQQDIVLADELSQEVCILSADVVVGIAAPGCPNALKGKTVLENFVEENLIAPVFSIHHARFQDGEHFGEIIFGGSDWKYVDGEFTYVPLVGDDSWKFRLDGVKIGDTTVAPAGTQAIIDTSKAIIVGPKAYVNPINEAIGCVVEKTTTRRICKLDCSKIPSLPDVTFVINGRNFNISSQYYIQQNGNLCYSGFQPCGHSDHFFIGDFFVDHYYSEFNWENKTMGFGRSVE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: SER30 THR31 ALA32 TYR49 SER50 SER52 TYR53 GLY66 SER67 HIS91 TYR92 ASN93 SER94 GLN96 F: LYS30 ASP31 THR32 TYR33 HIS35 TRP47 ARG50 ASP52 ALA54 ARG59 TRP99 VAL100 ARG101 GLN102 B: GLU44 LYS58 LEU59 LYS60 PRO61 LYS65 TYR66 ILE67 ASP68 GLY69 ASN70 VAL71 GLN72 ARG83 GLU86 GLN98 ASP100 PRO128 ALA130 LEU131 LYS132 GLY133 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
