Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2956 |
| PDBID: | 6UTE |
| Chains: | CD_S |
| Organism: | Homo sapiens, West Nile virus |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1073/pnas.1919269117 |
| Antibody | |
| Antibody: | Z032 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | West Nile virus envelope domain III |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6UTE_C|Chain A, D[auth C], F[auth E], H[auth G], J[auth I]|Z032 Fab heavy chain|Homo sapiens (9606) EVQLLESGGRLVQPGGSLTLSCAASGFPFSTYAMSWLRQAPGKGLEWVSGITGDSGSTYYAASVKGRFTISRDNSKNTLYLQMNSLTADDTAVYYCAKDRLHSGLGELFSYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHH |
Light Chain: D
Mutation: NULL
| >6UTE_D|Chain B, E[auth D], G[auth F], I[auth H], K[auth J]|Z032 Fab light chain|Homo sapiens (9606) DIQMTQSPSTLSASVGDRVNITCRASQSINQWLAWYQQKPGKAPKFLMYKASTLETGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQHYFSYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: S
Mutation: NULL
| >6UTE_S|Chain C[auth S]|Envelope domain III|West Nile virus (11082) GVCSKAFKFLGTPADTGHGTVVLELQYTGTDGPCKVPISSVASLNDLTPVGRLVTVNPFVSVATANAKVLIELEPPFGDSYIVVGRGEQQINHHWHKS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: ASP53 GLY55 SER56 TYR58 ASP95 ARG96 LEU97 HIS98 SER99 D: TRP32 TYR49 TYR91 PHE92 SER93 TYR94 S: GLY303 VAL304 SER306 LYS307 ASP333 LEU346 ASN347 LEU349 ARG388 GLY389 GLU390 GLN391 GLN392 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
