Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2954 |
| PDBID: | 6UTA |
| Chains: | HL_E |
| Organism: | Homo sapiens, Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 |
| Method: | XRD |
| Resolution (Å): | 3.10 |
| Reference: | 10.1073/pnas.1919269117 |
| Antibody | |
| Antibody: | Z004 iGL Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Zika envelope domain III |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6UTA_H|Chain A, D[auth H]|Z004 iGL Fab heavy chain|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDRGPRGVGELFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHH |
Light Chain: L
Mutation: NULL
| >6UTA_L|Chain B, E[auth L]|Z004 iGL Fab light chain|Homo sapiens (9606) DIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKLLIYKASSLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYNSYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >6UTA_E|Chain C, F[auth E]|Env|Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 (2043570) MRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRSGSTI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLY55 SER56 THR57 TYR58 ARG96 GLY97 PRO98 ARG99 L: GLN27 TRP32 LYS50 TYR91 ASN92 SER93 TYR94 TRP96 E: SER304 TYR305 SER306 LEU307 CYS308 THR309 ALA310 ALA311 ALA333 GLY334 THR335 ASP336 LYS340 THR351 LEU352 GLU370 VAL391 GLY392 GLU393 LYS394 LYS395 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
