Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2949 |
| PDBID: | 6URH |
| Chains: | HL_C |
| Organism: | Hepacivirus hominis, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.20 |
| Reference: | 10.7554/eLife.53169 |
| Antibody | |
| Antibody: | AR3X Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hepatitis C virus envelope glycoprotein E2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6URH_H|Chain B[auth H]|AR3X Heavy Chain|Homo sapiens (9606) QVQLEQSGAEVKKPGSSVKVSCKASGGTFSSFVINWVRQAPGQGLEWVGGIFQAPGPEREWLRDINPISGTINYAQRFQGRVTMTADESMTTVYMELSSLRSEDTAMYYCARENKFRYCRGGSCYSGAFDMWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHH |
Light Chain: L
Mutation: NULL
| >6URH_L|Chain C[auth L]|AR3X Light Chain|Homo sapiens (9606) EIELTQSPATLSVSPGESATLSCRASQSVSDNLAWYQQKPGQAPRLLIYGASSRAPAIPGRFSGSGSGTDFTLTISRLEPEDLAVYHCQQYGASPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >6URH_C|Chain A[auth C]|HCV envelope glycoprotein E2|Hepacivirus C (3052230) STHVTGGTASHTTRHFASLFSSGASQRVQLINTNGSWHINRTALNCNDSLHTGFLAALFYTHKFNASGCPERMAHCRPIDEFAQGWGPITYAEGHGSDQRPYCWHYAPRQCGTIPASQVCGPVYCFTPSPVVVGTTDRFGAPTYTWGENETDVLILNNTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGVGNNTLTCPTDCFRKHPEATYTKCGSGPWLTPRCLVDYPYRLWHYPCTVNFTIFKVRMYVGGVEHRLNAACNIG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER30 SER31 PHE32 ILE53 ARG94 ASN96 PHE98 ARG99 ASP101 L: PRO56 C: TRP420 ILE422 THR425 LEU427 ASN428 CYS429 ASN430 ASP431 SER432 HIS434 GLY436 LEU438 ALA439 ALA440 LEU441 PHE442 TYR443 THR444 HIS445 LYS446 PRO505 TRP529 GLU531 PRO612 TYR613 LEU615 TRP616 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
