Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2948 |
| PDBID: | 6UR5 |
| Chains: | GH_D |
| Organism: | Homo sapiens, Influenza A virus |
| Method: | XRD |
| Resolution (Å): | 4.00 |
| Reference: | 10.1021/acsinfecdis.0c00008 |
| Antibody | |
| Antibody: | K03.12 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >6UR5_G|Chain A, E[auth G]|Antibody heavy chain|Homo sapiens (9606) ASQVQLVQSGAEVKKPGASVKVSCKTSGYTFTAYYLHWVRQAPGQGFEWMAWINPNTGDTNYAQKFQGRVTLSRDTSITTAYMELTRLRSDDTAVYYCAKDLTLMYVFDSGWARGAHDYYGMDVWGQGTTVAVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: H
Mutation: NULL
| >6UR5_H|Chain B, F[auth H]|Antibody light chain|Homo sapiens (9606) ASPSALTQPASVSGSPGQSVTISCTGTNSDVGTFDLVSWYQQYPGKAPKLIIYEGSRRPSGVSDRFSGSKSGNTASLTISGLQAEDEADYYCSSYAGSVVFGGGTKLTVLGQPKGAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: D
Mutation: NULL
| >6UR5_D|Chain C, D|Influenza hemagglutinin HA1|Influenza A virus (11320) ASVAAQELVESQHLPELCPSPLRLVDGQTCDIVNGALGSPGCDHLNGAEWDIFIERPTAVDTCYPFDVPDYQSLRSILANNGKFEFIAEEFQWSTVKQNGVSASCSRANVNDFFNRLNWLTGKNGLYPLQNLTKINNGDYARLYIWGVHHPPNIGDQTNLYKNNPGRVTVSTKTSQTSVVPNIGSRPKVRDQEGRISFYWTIVEPGDLIVFNTIGNLIAPRGHYKLNSQKKSTILNTAVPIGSCVSKCHTDRGSITTTKPFQNISRISIGDCPKYVKQGSLKLATGGALEVLFQG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: LEU102 TYR104 VAL105 PHE106 ASP107 SER108 GLY109 TRP110 ALA111 ARG112 GLY113 ASP116 TYR118 H: TYR51 GLU52 ARG55 D: TYR98 LYS131 ASN133 GLY134 VAL135 SER136 ALA137 ASN145 TRP153 THR155 GLY156 LYS157 ASN158 GLY159 LEU160 HIS183 PRO186 ASN187 ASP190 ASN193 LEU194 GLN226 GLU227 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
