Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2922 |
| PDBID: | 6UJ9 |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1038/s41467-021-25605-4 |
| Antibody | |
| Antibody: | 2Q1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HLA class I histocompatibility antigen, B-7 alpha chain |
| Antigen mutation: | No |
| Durg Target: | P01889 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6UJ9_H|Chain E[auth H]|Fab heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFNVKYYMMHWVRQAPGKGLEWVAAISPGYDYTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRSYWRYSVDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP |
Light Chain: L
Mutation: NULL
| >6UJ9_L|Chain D[auth L]|Fab light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQVYSSPFTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >6UJ9_A|Chain A|HLA class I histocompatibility antigen, B-7 alpha chain|Homo sapiens (9606) MGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSGSLHHILDAQKMVWNHR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ASP28 ASN30 TYR49 SER50 PHE53 LEU54 SER56 TYR92 SER93 SER94 PHE96 H: ASN28 LYS30 TYR31 TYR32 MET33 SER52 PRO53 GLY54 ASP56 TYR57 TYR59 TYR100 TRP101 ARG102 TYR103 A: GLN65 ILE66 LYS68 ALA69 GLN72 THR73 GLU76 ARG79 ASN80 ARG82 GLY83 TYR84 ASN86 GLN87 SER88 GLU89 ILE142 ARG145 LYS146 ALA149 ALA150 ARG151 GLU152 GLU154 GLN155 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
