Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 291 |
| PDBID: | 2JIX |
| Chains: | FA_C |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1182/blood-2007-04-083998 |
| Antibody | |
| Antibody: | ABT-007 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | erythropoietin receptor (EPOR) |
| Antigen mutation: | No |
| Durg Target: | P19235 |
Sequence information
Antibody
Heavy Chain: F
Mutation: NULL
| >2JIX_F|Chain D, F, H|ABT-007 FAB FRAGMENT|HOMO SAPIENS (9606) QVQLQESGPGLVKPSETLSLTCTVSGASISSYYWSWIRQPPGKGLEWIGYIGGEGSTNYNPSLKSRVTISVDTSKNQFSLKLRSVTAADTAVYYCARERLGIGDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Light Chain: A
Mutation: NULL
| >2JIX_A|Chain A, G, I[auth L]|ABT-007 FAB FRAGMENT|HOMO SAPIENS (9606) DIQLTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKRLIYAASSLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQHNTYPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >2JIX_C|Chain B, C, E|ERYTHROPOIETIN RECEPTOR|HOMO SAPIENS (9606) APPPNLPDPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ARG30 ASN31 ASP32 TYR49 ALA50 SER53 HIS91 ASN92 TYR94 F: SER31 TYR32 TYR33 TYR50 GLU54 SER56 THR57 ASN58 GLU98 ARG99 LEU100 C: ARG21 GLU25 LEU27 SER56 GLN58 GLU60 ASP61 GLU62 PRO63 TRP64 PRO95 GLU97 ARG99 THR101 SER104 GLY105 ALA106 PRO107 ARG108 TYR109 HIS110 ARG111 VAL112 HIS114 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
