Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2902 |
| PDBID: | 6U9S |
| Chains: | DE_F |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.40 |
| Reference: | 10.7554/eLife.52337 |
| Antibody | |
| Antibody: | 5A6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | CD81 antigen |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >6U9S_D|Chain A, D|5A6 FAB Heavy Chain|Mus musculus (10090) QVQLVQSGSELKKPGASVKVSCKASGYTFTDDSIHWVRQAPGQGLEWMGWINTETGEPTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCARLSPVVVIFIYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCGGSGLEVLFQ |
Light Chain: E
Mutation: NULL
| >6U9S_E|Chain B, E|5A6 FAB Light Chain|Mus musculus (10090) DIVMTQSPLSLPVTPGEPASISCKSSQSLLHSRTRKNYLAWYLQKPGQSPQLLIYWASTRESGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCKQSYNLYAFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: F
Mutation: NULL
| >6U9S_F|Chain C, F|CD81 antigen|Homo sapiens (9606) ETGFVNKDQIAKDVKQFYDQALQQAVVDDDANNAKAVVKTFHETLDCCGSSTLTALTTSVLKNNLCPSGSNIISNLFKEDCHQKIDDLFSGSHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: GLN1 TYR27 ASP31 ASP32 SER33 TRP50 ASN52 THR53 GLU54 ARG98 LEU99 SER100 PRO101 VAL102 VAL103 VAL104 ILE107 TYR108 E: HIS31 ARG33 THR34 ARG35 LYS36 TYR38 TYR55 TRP56 THR59 ARG60 GLU61 SER62 SER97 TYR98 TYR101 F: CYS157 SER160 THR163 ALA164 THR166 THR167 SER168 LEU170 LYS171 ASN173 CYS175 SER177 GLY178 SER179 ASN180 ILE181 ILE182 ASN184 LEU185 PHE186 LYS187 GLU188 ASP189 GLN192 HIS202 HIS203 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
