Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 29 |
| PDBID: | 1EO8 |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/X-31(H3N2)), Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | BH151 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1EO8_H|Chain D[auth H]|ANTIBODY (HEAVY CHAIN)|Mus musculus (10090) QVQLQQSGAELMKPGPSVKISCKATGYSFSTYFIEWIRQRPGHGLEWIGEILPGSDNTNFNEKFKDRATFTADTPSNTAYMQLSSLTSEDSAVYYCARPTGRLWFSYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVP |
Light Chain: L
Mutation: NULL
| >1EO8_L|Chain C[auth L]|ANTIBODY (LIGHT CHAIN)|Mus musculus (10090) QIILTQSPAIMSASPGEKVTMTCSASSDISYMHWYQQKSDTSPKIWIYDTSKLASGVPARFSGSGSGTSYSLTISTMEAEDAATYYCHQRSSYPTFGGGTKLEIKRADAAPTVSIFPPSKIQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: A
Mutation: NULL
| >1EO8_A|Chain A|HEMAGGLUTININ (HA1 CHAIN)|Influenza A virus (A/X-31(H3N2)) (132504) QDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGIHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR49 SER56 GLY57 H: GLN1 VAL2 THR25 GLY26 TYR27 SER28 PHE29 SER30 THR31 TYR32 SER54 ASN56 ASN76 ARG94 THR96 ARG98 PHE100 TYR102 A: LYS50 ARG57 LEU59 ASP60 ILE62 ASP63 CYS64 PRO74 HIS75 ASP77 VAL78 PHE79 GLU82 ARG90 LYS92 PHE94 SER95 ASN96 GLY142 PRO143 ARG224 ASP271 PRO273 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
