Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2896 |
| PDBID: | 6U55 |
| Chains: | A_B |
| Organism: | Lama glama, Sudan virus - Boniface, Sudan,1976 |
| Method: | XRD |
| Resolution (Å): | 1.93 |
| Reference: | 10.1016/j.jmb.2019.10.005 |
| Antibody | |
| Antibody: | Zaire E (ZE) VH-sdAb |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Zaire ebolavirus Nucleoprotein C-terminal Domain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: A
Mutation: NULL
| >6U55_A|Chain A|Anti-Zaire ebolavirus Nucleoprotein Single Domain Antibody Zaire E (ZE)|Lama glama (9844) QVQLQESGGGLVQPGGSLRLSCTASGFTLAEYGVGWFRQAPGKERELVALIAVGGTTHSIDSVKGRFTISRDNMKNTVYLQMNSLNVEDTAVYYCNAYSSAYDRNYWGQGTQVTVSS |
Antigen
Chain: B
Mutation: NULL
| >6U55_B|Chain B|Nucleoprotein|Sudan ebolavirus (strain Boniface-76) (128948) KIHHHHHHGGGSESEALPINSKKSSALEETYYHLLKTQGPFEAINYYHLMSDEPIAFSTESGKEYIFPDSLEEAYPPWLSEKEALEKENRYLVIDGQQFLWPVMSLRDKFLAVLQHD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: GLY33 GLY35 PHE37 GLU44 ARG45 GLU46 LEU47 LEU50 ALA52 VAL53 THR56 HIS58 ILE60 ASP61 ASN96 TYR98 SER100 ASP103 ASN105 TRP107 B: SER645 SER646 ALA647 LEU648 THR651 HIS654 LEU655 LYS657 THR658 GLN659 PHE662 GLU663 ASN666 TYR667 LEU670 MET671 SER672 ASP673 ARG728 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
