Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 289 |
| PDBID: | 2JEL |
| Chains: | H_P |
| Organism: | Mus musculus, Escherichia coli |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1006/jmbi.1998.1888 |
| Antibody | |
| Antibody: | JEL42 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HISTIDINE-CONTAINING PROTEIN |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: H
Mutation: NULL
| >2JEL_H|Chain B[auth H]|JEL42 FAB FRAGMENT|Mus musculus (10090) QVQLAQSGPELVRPGVSVKISCKGSGYTFTTYAMHWVKQSHAKSLEWIGLISTYSGYTNYNQKFKGKATMTVDKSSSTAYMELARLTSEDSAIYYCARVMGEQYFDVWGAGTTVIVSSAATTPPSVYPLAPGSGGQGNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLAADLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIAPG |
Antigen
Chain: P
Mutation: NULL
| >2JEL_P|Chain C[auth P]|HISTIDINE-CONTAINING PROTEIN|Escherichia coli (562) MFQQEVTITAPNGLHTRPAAQFVKEAKGFTSEITVTSNGKSASAKSLFKLQTLGLTQGTVVTISAEGEDEQKAVEHLVKLMAELE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR30 THR31 ALA33 HIS35 LEU50 THR52 TYR53 SER54 TYR56 ASN58 VAL95 MET96 GLY97 GLU98 P: MET1 PHE2 GLN3 GLN4 GLU5 GLU66 GLY67 GLU68 GLU70 GLN71 LYS72 GLU75 HIS76 LYS79 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
