Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 288 |
| PDBID: | 2J88 |
| Chains: | HL_A |
| Organism: | Apis mellifera, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1016/j.jmb.2007.02.036 |
| Antibody | |
| Antibody: | 21E11 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hyaluronidase |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >2J88_H|Chain B[auth H]|FAB|MUS MUSCULUS (10090) QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSGMGVSWIRQPSGKGLEWLAHIYWDDDKRYNPSLKSRLTISKDTSRNQVFLKITSVDTADTATYYCTLYYGSVDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSST |
Light Chain: L
Mutation: NULL
| >2J88_L|Chain C[auth L]|FAB|MUS MUSCULUS (10090) DIQMTQSPASLSASVGETVTITCRASENIYSYLTWYQQKQGKSPQLLVYNAKTLAEGVPSRFSGSGSGTQFSLKISSLQPEDFGNYYCQHHYGTRTFGGGTRLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >2J88_A|Chain A|HYALURONONGLUCOSAMINIDASE|APIS MELLIFERA (7460) TPDNNKTVREFNVYWNVPTFMCHKYGLRFEEVSEKYGILQNWMDKFRGEEIAILYDPGMFPALLKDPNGNVVARNGGVPQLGNLTKHLQVFRDHLINQIPDKSFPGVGVIDFESWRPIFRQNWASLQPYKKLSVEVVRREHPFWDDQRVEQEAKRRFEKYGQLFMEETLKAAKRMRPAANWGYYAYPYCYNLTPNQPSAQCEATTMQENDKMSWLFESEDVLLPSVYLRWNLTSGERVGLVGGRVKEALRIARQMTTSRKKVLPYYWYKYQDRRDTDLSRADLEATLRKITDLGADGFIIWGSSDDINTKAKCLQFREYLNNELGPAVKRIALNNNANDRLTVDVSVDQV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLY33 TYR52 TRP53 ASP54 ASP56 ARG58 TYR95 TYR96 GLY97 SER98 VAL99 ASP100 L: TYR30 SER31 TYR32 THR34 TYR36 LEU46 TYR49 ASN50 HIS91 TYR92 GLY93 ARG96 A: ARG138 ARG139 GLU140 HIS141 PRO142 PHE143 TRP144 ASP145 ASP146 GLN147 ARG148 VAL149 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
