Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2870 |
| PDBID: | 6TYB |
| Chains: | HL_G |
| Organism: | Simian immunodeficiency virus, Macaca mulatta |
| Method: | XRD |
| Resolution (Å): | 2.30 |
| Reference: | 10.1016/j.immuni.2019.09.007 |
| Antibody | |
| Antibody: | ITS90.03 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SIV gp160 |
| Antigen mutation: | No |
| Durg Target: | P05884 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6TYB_H|Chain C[auth H]|NEUTRALIZING ANTIBODY ITS90.03 FAB HEAVY CHAIN|Macaca mulatta (9544) EVQLVQSGTEVKRPGESLTISCKTSGYSFSGTWISWVRQMPGKGLEWMGSIYPGDSDTRYHPSFQGHVTISADRSVSTTYLQWSSLKASDTATYYCARSYEDNYGYYDLFFFFDYWGQGALVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKGLEVLFQ |
Light Chain: L
Mutation: NULL
| >6TYB_L|Chain D[auth L]|NEUTRALIZING ANTIBODY ITS90.03 FAB LIGHT CHAIN|Macaca mulatta (9544) DIQMTQSPSSLSASVGDRVTITCRASQGISTYLAWYQQKPGKAPKLLIYKAYLLQNGVPSRFSGGGSGTDFTLTISSLQPEDFATYYCQQHNNNPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: G
Mutation: NULL
| >6TYB_G|Chain A[auth G]|Envelope glycoprotein gp160|Simian immunodeficiency virus (11723) AWRNATIPLFCATKNRDTWGTTQCLPDNGDYSEVALNVTESFDAWNNTVTEQAIEDVWQLFETSIKPCVKLSGSGSVIQESCDKHYWDAIRFRYCAPPGYALLRCNDTNYSGFMPKCSKVVVSSCTRMMETQTSTWFGFNGTRAENRTYIYWHGRDNRTIISLNKYYNLTMKCRRPGGSGGSGDRPKQAWCWFGGKWKDAIKEVKQTIVKHPRYTGTNNTDKINLTAPGGGDPEVTFMWTNCRGEFLYCKMNWFLNWVEDRNTANQKPKEQHKRNYVPCHIRQIINTWHKVGKNVYLPPREGDLTCNSTVTSLIANIDWIDGNQTNITMSAEVAELYRLELGDYKLVEITPGLEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER28 SER30 GLY31 TRP33 GLY53 ASP54 ASP56 ARG73 GLU97 ASP98 ASN99 L: SER30 THR31 TYR32 TYR49 LYS50 TYR52 LEU53 G: ASN88 VAL89 THR90 THR231 ASN232 SER234 PHE236 MET237 LYS238 SER240 LYS241 TYR271 TRP274 THR348 VAL350 LYS351 HIS352 PRO353 ARG354 TYR355 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
