Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2865 |
| PDBID: | 6TOU |
| Chains: | A_G |
| Organism: | Lyssavirus rabies, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.59 |
| Reference: | 10.1038/s41467-020-14398-7 |
| Antibody | |
| Antibody: | RVC20 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Rabies virus glycoprotein PH domain |
| Antigen mutation: | No |
| Durg Target: | P08667 |
Sequence information
Antibody
Chain: A
Mutation: NULL
| >6TOU_A|Chain B[auth A]|Single-chain Fv|Homo sapiens (9606) QVQLQESGPGLVKPSQTLSLTCTVSGGSFSSGSYSWNWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVTMSVHTSKNQFSLKLNSITAADTAVYYCARGTYSDFWSGSPLDYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGGDIQMTQSPSSLSASVGDRVTITCRASQGISNYLAWFQQKPGKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTINSLQPEDFVTYFCQQYDTYPLTFGGGTKVEIKGGWSHPQFEK |
Antigen
Chain: G
Mutation: NULL
| >6TOU_G|Chain A[auth G]|Glycoprotein,Glycoprotein|Rabies lyssavirus (11292) EDEGCTNLSGFSYMELKVGYISSIKVGGGNPRLGTSCDIFTNSRGKRASKGSKTCGFVDERGLYKSLKGACKLKLCGVLGLRLMDGTWVAMQTSDETKWCPPDQLVNLHDGGWSHPQFEK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: GLY32 SER33 TYR50 TYR52 SER54 SER56 THR57 TYR58 LYS64 TYR97 ASP99 GLY1000 ASP1092 THR1093 TYR1094 G: SER42 MET44 LYS47 GLY186 THR187 SER188 CYS189 ASP190 ILE191 PHE192 ASN194 LEU225 LYS226 LEU227 CYS228 GLY229 VAL230 LEU231 GLN244 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
