Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2862 |
| PDBID: | 6T9E |
| Chains: | AB_C |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.99 |
| Reference: | 10.1038/s41467-021-20949-3 |
| Antibody | |
| Antibody: | Duta Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Platelet-derived growth factor subunit B |
| Antigen mutation: | No |
| Durg Target: | P01127 |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6T9E_A|Chain A[auth AAA], E[auth HHH]|DutaFab mat VH chain|Homo sapiens (9606) DLQLVESGGGLVKPGGSLRLSCAADGWWFGYTDMSWVRQAPGKGLEWVGSISYKGGSTYYNTKFIGRFTISRDDDTNTLYLQMNSLRAEDTAVYYCARDDGYFDTWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYICNVNHKPSNTKVDKKVEPKSCT |
Light Chain: B
Mutation: NULL
| >6T9E_B|Chain B[auth BBB], F[auth LLL]|DutaFab mat VL chain|Homo sapiens (9606) AIQMTQSPSSLSASVGDRVTITCHGSYWLSNYLAWYQQKPGKAPKLLIYDGKEREHGVPSRFSGSGSHEDYTLTISSLQPEDFATYYCQQYRYHPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >6T9E_C|Chain C[auth CCC], D[auth DDD]|Platelet-derived growth factor subunit B|Homo sapiens (9606) SLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASP1 LEU2 ASP25 GLY26 TRP27 TRP28 TYR31 THR32 SER52 TYR53 LYS54 ARG98 ASP100 TYR102 ASP104 THR105 B: GLU55 HIS56 C: LEU38 VAL39 TRP40 PRO42 GLN71 ARG73 ILE75 ILE77 LYS80 LYS81 PRO82 PHE84 LYS86 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
