Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2858 |
| PDBID: | 6T3J |
| Chains: | CD_E |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.05 |
| Reference: | 10.1158/1535-7163.MCT-20-0044 |
| Antibody | |
| Antibody: | IgG1-hDR5-05 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Tumor necrosis factor receptor superfamily member 10B (DR5) |
| Antigen mutation: | No |
| Durg Target: | O14763; O14763; |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6T3J_C|Chain C, H|IgG1-hDR5-05-Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKASGFNIKDTHMHWVRQAPGQRLEWIGRIDPANGNTEYDQKFQGRVTITVDTSASTAYMELSSLRSEDTAVYYCARWGTNVYFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTHHHHHH |
Light Chain: D
Mutation: NULL
| >6T3J_D|Chain D, I|IgG1-hDR5-05-Light Chain|Homo sapiens (9606) DIQLTQSPSSLSASVGDRVTITCSASSSVSYMYWYQQKPGKAPKPWIYRTSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYHSYPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >6T3J_E|Chain E, J|Tumor necrosis factor receptor superfamily member 10B|Homo sapiens (9606) QQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGEPEA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: GLN1 VAL2 GLY26 PHE27 ASN28 ASP31 ARG98 THR101 ASN102 VAL103 TYR104 PHE105 TYR107 D: TYR31 ARG49 ASN52 E: SER74 SER75 PRO76 GLU78 GLY79 LEU80 ILE87 GLU89 ASP90 GLY91 HIS106 ASN108 ASP109 LEU110 LEU111 PHE112 LEU114 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
