Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2856 |
| PDBID: | 6T3J |
| Chains: | AB_E |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.05 |
| Reference: | 10.1158/1535-7163.MCT-20-0044 |
| Antibody | |
| Antibody: | IgG1-hDR5-01 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Benufutamab(Phase-I/II) |
| Antigen | |
| Antigen: | Tumor necrosis factor receptor superfamily member 10B (DR5) |
| Antigen mutation: | No |
| Durg Target: | O14763; O14763; |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6T3J_A|Chain A, F|IgG1-hDR5-01-Heavy Chain|Homo sapiens (9606) EVQLQQSGAEVVKPGASVKLSCKASGFNIKDTFIHWVKQAPGQGLEWIGRIDPANTNTKYDPKFQGKATITTDTSSNTAYMELSSLRSEDTAVYYCVRGLYTYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTHHHHHH |
Light Chain: B
Mutation: NULL
| >6T3J_B|Chain B, G|IgG1-hDR5-01-Light Chain|Homo sapiens (9606) EIVMTQSPATLSVSPGERATLSCRASQSISNNLHWYQQKPGQAPRLLIKFASQSITGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQGNSWPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >6T3J_E|Chain E, J|Tumor necrosis factor receptor superfamily member 10B|Homo sapiens (9606) QQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGEPEA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASN28 LYS30 ASP31 THR32 PHE33 ARG50 ASP52 ALA54 ASN55 LYS59 LEU100 TYR101 THR102 TYR103 B: GLN27 SER28 ASN31 ASN32 PHE50 GLN53 GLY91 ASN92 SER93 TRP94 TYR96 E: ARG115 ARG118 CYS119 ASP120 SER121 GLY122 GLU141 GLY142 THR143 GLU146 PRO150 MET152 CYS153 ARG154 LYS155 CYS156 ARG157 THR158 GLY159 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
