Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2855 |
| PDBID: | 6T3F |
| Chains: | HL_F |
| Organism: | Henipavirus nipahense, Oryctolagus cuniculus |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1073/pnas.1912503116 |
| Antibody | |
| Antibody: | 66 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Nipah virus fusion glycoprotein F0 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6T3F_H|Chain C[auth H]|Fab66 heavy chain|Oryctolagus cuniculus (9986) ETGSGGGLVKPGGTLTLTCKASGFTLSSYWMCWVRQAPGKGLELIACLYTNGATTWYASWVNGRFAISRSTSRNTVDLNMTSLTAADTATYFCARGSGSGWSWFNIWGPGTLVTVSSGQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLTNGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTVAPSTCNKGTKHHHHHH |
Light Chain: L
Mutation: NULL
| >6T3F_L|Chain B[auth L]|Fab66 light chain|Oryctolagus cuniculus (9986) ETGVMTQTPASVEAAVGGTVTIKCQASQNIISSLAWYQQKPGQRPKLLIYYASTLASGVPSRFKGSGSGTQFTLTISDLECADAATYYCQSYYYSGITYGNAFGGGTEVVVKGDPVAPTVLIFPPAADQVATGTVTIVCVANKYFPDVTVTWEVDGTTQTTGIENSKTPQNSADCTYNLSSTLTLTSTQYNSHKEYTCKVTQGTTSVVQSFSRKNC |
Antigen
Chain: F
Mutation: NULL
| >6T3F_F|Chain A[auth F]|Fusion glycoprotein F0|Nipah virus (3052225) ETGGILHYEKLSKIGLVKGVTRKYKIKSNPLTKDIVIKMIPNVSNMSQCTGSVMENYKTRLNGILTPIKGALEIYKNNTHDLVGDVRLAGVIMAGVAIGIATAAQITAGVALYEAMKNADNINKLKSSIESTNEAVVKLQETAEKTVYVLTALQDYINTNLVPTIDKISCKQTELSLDLALSKYLSDLLFVFGPNLQDPVSNSMTIQAISQAFGGNYETLLRTLGYATEDFDDLLESDSITGQIIYVDLSSYYIIVRVYFPILTEIQQAYIQELLPVSFNNDNSEWISIVPNFILVRNTLISNIEIGFCLITKRSVICNQDYATPMTNNMRECLTGSTEKCPRELVVSSHVPRFALSNGVLFANCISVTCQCQTTGRAISQSGEQTLLMIDNTTCPTAVLGNVIISLGKYLGSVNYNSEGIAIGPPVFTDKVDISSQISSMNQSLQQSKDYIKEAQRLLDGTMKQIEDKIEEILSKIYHIENEIARIKKLIGEGGSHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ASN28 ILE30 SER31 SER32 TYR50 TYR91 TYR92 TYR93 SER94 H: SER31 THR52 ASN53 THR56 SER96 GLY97 SER98 GLY99 F: LYS60 ILE62 PRO63 ASN64 VAL65 SER66 ASN67 SER69 GLN70 THR72 GLY73 SER74 MET76 GLU77 ASN78 LYS80 GLU152 SER153 ASN155 CYS192 LYS193 GLU196 SER272 SER273 TYR274 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
