Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2854 |
| PDBID: | 6SXI |
| Chains: | AB_L |
| Organism: | Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.85 |
| Reference: | 10.1038/s41541-020-00269-1 |
| Antibody | |
| Antibody: | anti-idiotype B2.1A Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | AP33 Fab light chain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6SXI_A|Chain C[auth A]|Single chain Fv - heavy chain|Mus musculus (10090) QVQLQESGTELVKPGASVKLSCKASGYTFTNYWMHWVKQRQGLEWIGEINPSDGHTNYNEKFKSKATLTVDKSSSTAYMQLSSLTSEDSAVYYCARPWAFGNYGAWFAYWGQGTLVTVS |
Light Chain: B
Mutation: NULL
| >6SXI_B|Chain D[auth B]|Single chain Fv - light chain|Mus musculus (10090) GASDIVMTQSPKFMSTSVGDRVSITCKASQNVRTAVAWYQQKPGQSPKALIYLASSRHTGVPDRFTGSGSGTDFTLTISNVQSEDLADYFCLQHWNYPYTFGGGTKLE |
Antigen
Chain: L
Mutation: NULL
| >6SXI_L|Chain B[auth L]|Fab light chain|Mus musculus (10090) NIVLTQSPVSLAVSLGQRATISCRASESVDGYGNSFLHWFQQKPGQPPKLLIYLASNLNSGVPARFSGSGSRTDFTLTIDPVEADDAATYYCQQNNVDPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TRP33 HIS35 GLU50 ASN58 PRO95 PHE98 GLY99 B: ARG30 THR31 LEU50 TRP92 TYR94 TYR96 L: ASN1 GLY27 TYR28 GLY29 PHE32 ASN91 ASN92 VAL93 ASP94 PRO95 TRP96 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
