Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2853 |
| PDBID: | 6SXI |
| Chains: | AB_H |
| Organism: | Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.85 |
| Reference: | 10.1038/s41541-020-00269-1 |
| Antibody | |
| Antibody: | anti-idiotype B2.1A Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | AP33 Fab heavy chain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6SXI_A|Chain C[auth A]|Single chain Fv - heavy chain|Mus musculus (10090) QVQLQESGTELVKPGASVKLSCKASGYTFTNYWMHWVKQRQGLEWIGEINPSDGHTNYNEKFKSKATLTVDKSSSTAYMQLSSLTSEDSAVYYCARPWAFGNYGAWFAYWGQGTLVTVS |
Light Chain: B
Mutation: NULL
| >6SXI_B|Chain D[auth B]|Single chain Fv - light chain|Mus musculus (10090) GASDIVMTQSPKFMSTSVGDRVSITCKASQNVRTAVAWYQQKPGQSPKALIYLASSRHTGVPDRFTGSGSGTDFTLTISNVQSEDLADYFCLQHWNYPYTFGGGTKLE |
Antigen
Chain: H
Mutation: NULL
| >6SXI_H|Chain A[auth H]|Fab heavy chain|Mus musculus (10090) EVQLQESGPSLVKPSQTLSLTCSVTGDSITSGYWNWIRKFPGNKLEYMGYISYSGSTYYNLSLRSRISITRDTSKNQYYLQLNSVTTEDTATYYCALITTTTYAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TYR27 ASN31 TYR32 ARG94 TRP96 ALA97 PHE98 TYR102 B: THR31 TYR49 LEU50 SER52 SER53 HIS55 THR56 SER67 H: TYR33 TYR50 TYR53 SER54 GLY55 SER56 THR57 TYR58 TYR59 LEU61 ARG64 ILE95 THR97 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
