Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2836 |
| PDBID: | 6SS6 |
| Chains: | EH_B |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.25 |
| Reference: | 10.1073/pnas.1919565117 |
| Antibody | |
| Antibody: | C0020187 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Arginase-2 |
| Antigen mutation: | No |
| Durg Target: | P78540 |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >6SS6_E|Chain D[auth HHH], E[auth III], F[auth JJJ]|Fab C0020187 heavy chain (IgG1)|Homo sapiens (9606) GAHSEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLRADLGLYMDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHAA |
Light Chain: H
Mutation: NULL
| >6SS6_H|Chain G[auth LLL], H[auth MMM], I[auth NNN]|Fab C0020187 light chain (IgG1)|Homo sapiens (9606) GVHSQSVLTQPPSVSAAPGQKVTISCSGSSSNIGNHYVSWYQQLPGTAPKLLIYDNSERPSGIPDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDSSLSALVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: B
Mutation: NULL
| >6SS6_B|Chain A[auth AAA], B[auth BBB], C[auth CCC]|Arginase-2, mitochondrial|Homo sapiens (9606) MVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRIGGGHHHHHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: THR32 SER34 SER35 TYR36 ALA37 SER56 GLY57 SER58 GLY59 GLY60 SER61 THR62 TYR63 LEU103 ALA105 ASP106 LEU107 GLY108 LEU109 H: HIS36 TRP96 SER98 SER101 B: GLN14 GLY15 GLN16 LYS17 ASP59 LEU60 TYR61 ASN63 LEU64 ILE65 LEU131 THR132 THR133 SER134 GLY136 PRO158 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
