Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2834 |
| PDBID: | 6SS4 |
| Chains: | BC_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1080/19420862.2020.1801230 |
| Antibody | |
| Antibody: | C0021181 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Arginase-2 |
| Antigen mutation: | No |
| Durg Target: | P78540 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6SS4_B|Chain B[auth HHH]|Fab C0021181 heavy chain (IgG1)|Homo sapiens (9606) GAHSEVQLLESGGGLVRPGGSLRLSCAASEFTFRYDYHVWVRQAPGKGLEWVSAISGSGGSTYYADSVKSRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLRADLGLYMDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHAA |
Light Chain: C
Mutation: NULL
| >6SS4_C|Chain C[auth LLL]|Fab C0021181 light chain (IgG1)|Homo sapiens (9606) GVHSQSVLTQPPSVSAAPGQKVAVSCSGSSSNIGSHYVSWYQQLPGTAPKLLIYDNSERTSGIPDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDELTSNLVFGGGTRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >6SS4_A|Chain A[auth AAA]|Arginase-2, mitochondrial|Homo sapiens (9606) MVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRIHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: PHE31 THR32 ARG34 TYR35 ASP36 TYR37 ALA54 GLY57 SER58 SER61 TYR63 LEU103 ARG104 ALA105 ASP106 LEU107 GLY108 LEU109 C: HIS36 TRP96 SER101 LEU103 A: GLN16 LYS17 LYS19 GLY20 HIS23 ALA26 GLU30 ASP58 ASP59 LEU60 TYR61 ASN63 LEU64 ILE65 PRO278 GLN279 ALA281 THR282 SER283 GLU284 ALA287 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
