Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2833 |
| PDBID: | 6SS2 |
| Chains: | BC_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.40 |
| Reference: | 10.1080/19420862.2020.1801230 |
| Antibody | |
| Antibody: | C0021158 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Arginase-2 |
| Antigen mutation: | No |
| Durg Target: | P78540 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6SS2_B|Chain B[auth HHH]|Fab C0021158 heavy chain (IgG1)|Homo sapiens (9606) GAHSEVQLLESGGGLVQPGGSLRLSCAASGFTFRYEVAAWVRQAPGKGLEWVSAISGPIPKGYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLRADLGLYMDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHAA |
Light Chain: C
Mutation: NULL
| >6SS2_C|Chain C[auth LLL]|Fab C0021158 light chain (IgG1)|Homo sapiens (9606) GVHSQSVLTQPPSVSAAPGQKVTISCSGSSSNIGNHYVSWYQQLPGTAPKLLIYDNSERTAGVPDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDELTSNLVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >6SS2_A|Chain A[auth AAA]|Arginase-2, mitochondrial|Homo sapiens (9606) MVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRIHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: GLY30 THR32 ARG34 TYR35 GLU36 VAL37 TRP51 ALA54 SER56 GLY57 PRO58 ILE59 LYS61 TYR63 LEU103 ARG104 ALA105 ASP106 LEU107 GLY108 LEU109 C: HIS36 TRP96 GLU98 SER101 LEU103 A: PRO11 GLN16 LYS17 LYS19 GLY20 GLU22 HIS23 ALA26 ALA27 GLU30 LEU50 SER51 PHE52 THR53 LYS57 ASP58 ASP59 LEU60 TYR61 ASN63 LEU64 ILE65 PRO278 GLN279 THR282 GLU284 ALA287 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
