Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2827 |
| PDBID: | 6SNE |
| Chains: | BA_O |
| Organism: | Human immunodeficiency virus 1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.90 |
| Reference: | 10.1016/j.chom.2019.09.016 |
| Antibody | |
| Antibody: | LN01 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 gp41 |
| Antigen mutation: | No |
| Durg Target: | P12488 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6SNE_B|Chain C[auth B], E[auth D], H[auth F], K[auth H]|LN01 heavy chain|Homo sapiens (9606) EVQLVESGPGLVQPWGTLSLTCRVSGDSVSNDNYYWAWIRQTPGRELQVIGTIYYSGTTYYNPSLRNRVTISLDKSVNVVSLRLGSVSAADTAQYYCVRMPSHGFWSTSFSYWYFDLWGRGHFVAVSWASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVDHKPSNTKVDKKVEPKSCDTTS |
Light Chain: A
Mutation: NULL
| >6SNE_A|Chain B[auth A], D[auth C], G[auth E], J[auth L]|LN01 light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDKVTITCRASQSVTKYLNWYQFKTGQAPRILIYGTYTLLSGVSPRFSGAGSGSLYTLTITNIQPEDFATYYCQQAHSTPWTFGQGTHVAANRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGGC |
Antigen
Chain: O
Mutation: NULL
| >6SNE_O|Chain A[auth J], F[auth N], I[auth O], L[auth P]|Envelope glycoprotein gp160|Human immunodeficiency virus 1 (11676) GQNQQEKNEQELLELDKWASLWNWFNITNWLWYIKLFIMIVGGLVGLRIVFAVLSVVNRVRQG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: THR30 TYR32 ALA91 HIS92 SER93 THR94 TRP96 B: THR50 TYR58 MET95 O: ASN671 TRP672 PHE673 ASN674 THR676 ASN677 LEU679 TRP680 TYR681 ILE682 LYS683 ILE686 MET687 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
