Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2810 |
| PDBID: | 6S3D |
| Chains: | AB_N |
| Organism: | Homo sapiens, synthetic construct |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1126/science.aay5051 |
| Antibody | |
| Antibody: | D25 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | S0_2.126 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6S3D_A|Chain A, C, E, G[auth H]|Heavy Chain|Homo sapiens (9606) TRQVQLVQSGAEVKKPGSSVMVSCQASGGPLRNYIINWLRQAPGQGPEWMGGIIPVLGTVHYAPKFQGRVTITADESTDTAYIHLISLRSEDTAMYYCATETALVVSTTYLPHYFDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDGTKHHHHHH |
Light Chain: B
Mutation: NULL
| >6S3D_B|Chain B, D, F, H[auth L]|Light Chain|Homo sapiens (9606) TRDIQMTQSPSSLSAAVGDRVTITCQASQDIVNYLNWYQQKPGKAPKLLIYVASNLETGVPSRFSGSGSGTDFSLTISSLQPEDVATYYCQQYDNLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGTKHHHHHH |
Antigen
Chain: N
Mutation: NULL
| >6S3D_N|Chain I[auth M], J[auth N], K[auth O], L[auth P]|S0_2.126|synthetic construct (32630) ASPCDKQKNYIDKQLLPIVNKAGCSRPEEVEERIRRALKKMGDTSCFDEILKGLKEIKCGGSWLEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ARG32 ASN33 VAL56 LEU57 GLU101 THR102 ALA103 LEU104 VAL105 VAL106 SER107 THR108 THR109 TYR110 LEU111 HIS113 TYR114 ASP116 B: VAL32 ASN33 TYR34 TYR51 VAL52 ASN55 GLU57 THR58 TYR93 ASP94 N: LYS8 ASN9 TYR10 ASP12 LYS13 GLN14 LEU16 PRO17 ILE18 VAL19 ASN20 LYS21 CYS24 VAL30 LYS52 GLY53 LEU54 LYS55 GLU56 ILE57 LYS58 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
