Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2804 |
| PDBID: | 6RQM |
| Chains: | B_A |
| Organism: | Camelus bactrianus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | blocking-KN044 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | Erfonrilimab(Phase-III) |
| Antigen | |
| Antigen: | Cytotoxic T-lymphocyte protein 4(CTLA-4) |
| Antigen mutation: | No |
| Durg Target: | P16410 |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >6RQM_B|Chain A[auth B]|A blocking anti-CTLA-4 nanobody (KN044)|Camelus bactrianus (9837) QVQLVESGGGLVQPGGSLRLSCAASGYIYSAYCMGWFRQAPGKGLEGVAAIYIGGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAADVIPTETCLGGSWSGPFGYWGQGTLVTVSSGSMDPGGSHHHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >6RQM_A|Chain B[auth A]|Cytotoxic T-lymphocyte protein 4|Homo sapiens (9606) AMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition B: GLN1 TYR27 TYR29 SER30 ALA31 TYR32 CYS33 TYR52 GLY55 ASP99 VAL100 ILE101 PRO102 THR103 GLU104 PRO114 PHE115 GLY116 TYR117 A: HIS4 VAL5 ARG35 LEU39 GLN41 SER44 GLN45 VAL46 THR47 GLU48 LEU91 ILE93 LYS95 GLU97 MET99 TYR104 TYR105 LEU106 GLY107 ILE108 GLY109 ASN110 GLY111 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
