Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 28 |
| PDBID: | 1EGJ |
| Chains: | HL_A |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | BION-1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | CYTOKINE RECEPTOR COMMON BETA CHAIN PRECURSOR |
| Antigen mutation: | No |
| Durg Target: | P32927 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1EGJ_H|Chain C[auth H]|ANTIBODY (HEAVY CHAIN)|Mus musculus (10090) EVQLQQSGPELVKPGTSVKMSCKASGYTFTDYYMKWVKHSHGKSLEWIGDINPSNGGTLYNQKFKGKATLTVDKSSSTASMQLSRLTSEDSAVYYCSRGDGIHGGFAYWGQGTTVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIVPQV |
Light Chain: L
Mutation: NULL
| >1EGJ_L|Chain B[auth L]|ANTIBODY (LIGHT CHAIN)|Mus musculus (10090) NIVLTQSPASLAVSLGQRATISCRANESVYSYGDSFMHWYQQKPGQPPKLLIYLASNLASGVPARFSGSGSRTDFTLTIDPVETDDAATYYCQQNNEDPWTFGGGTKLEIKRGDAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDANVAWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR |
Antigen
Chain: A
Mutation: NULL
| >1EGJ_A|Chain A|CYTOKINE RECEPTOR COMMON BETA CHAIN PRECURSOR|Homo sapiens (9606) IQMAPPSLNVTKDGDSYSLRWETMKMRYEHIDHTFEIQYRKDTATWKDSKTETLQNAHSMALPALEPSTRYWARVRVRTSRTGYNGIWSEWSEARSWDTES |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR28 GLY29 ASP30 PHE32 LEU50 ASN91 ASN92 GLU93 ASP94 TRP96 H: TYR32 TYR33 LYS35 ASP50 ASN53 GLY55 THR57 LEU58 GLY95 GLY96 ILE97 HIS98 A: ILE338 LYS362 MET363 ARG364 TYR365 GLU366 HIS367 ILE368 HIS395 THR416 ARG418 THR419 TYR421 ASN422 GLY423 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
