Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2798 |
| PDBID: | 6RPJ |
| Chains: | B_A |
| Organism: | Homo sapiens, Camelus bactrianus |
| Method: | XRD |
| Resolution (Å): | 3.25 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | non-blocking-CTLA-4 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Cytotoxic T-lymphocyte protein 4(CTLA-4) |
| Antigen mutation: | No |
| Durg Target: | P16410 |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >6RPJ_B|Chain B, D, F, H|A non-blocking CTLA-4 nanobody|Camelus bactrianus (9837) QVQLQESGGGSVQAGGSLTLSCAASGYANSNTCMGWFRQAPGKERERVAAISGVGTGTYYADSVKGRFTISRDNGKNTLFLQMNSLKPEDTAMYYCAAAPEGRAWCSRDPSGYNYWGQGTQVTVSSGSMDPGGSHHHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >6RPJ_A|Chain A, C, E, G|Cytotoxic T-lymphocyte protein 4|Homo sapiens (9606) AMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPGGSHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: ALA28 ASN29 SER30 ASN31 ARG47 SER52 VAL54 GLY55 THR56 GLY57 TYR59 ASN74 LYS76 GLY102 ARG103 ALA104 TRP105 CYS106 SER107 ARG108 ASP109 A: ARG40 GLN45 VAL46 THR47 GLU48 VAL49 CYS50 ALA51 LEU63 ASP64 ASP65 SER66 ILE67 GLY83 LEU84 ARG85 MET87 ASP88 TYR92 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
