Details
Structure visualisation
Entry information
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >6RLO_G|Chain A, D[auth C], G[auth E], J[auth G]|AT1412dm Fab Fragment (Heavy Chain)|Homo sapiens (9606) EVQVVESGGGLVQPGRSLRLSCAASGFTFDDYAMYWVRQAPGKGLEWVSGISWNSGSIVYADSVKGRFTISRDNAKNSLYLQLNSLRAEDTAFYYCAKAVSGYFPYFDYWGQGILVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: H
Mutation: NULL
| >6RLO_H|Chain B, E[auth D], H[auth F], K[auth H]|AT1412dm Fab Fragment (Light Chain)|Homo sapiens (9606) DIVMTQSPDSLSVSLGERATINCKSSQSVLYSSNNKNYLGWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYTTPSTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: L
Mutation: NULL
| >6RLO_L|Chain C[auth I], F[auth J], I[auth K], L|CD9 antigen|Homo sapiens (9606) MGSKDEVIKEVQEFYKDTYNKLKTKDEPQRETLKAIHYALNCCGLAGGVEQFISDICPKKDVLETFTVKSCPDAIKEVFDNAAAHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: ASP35 ASP36 TYR37 ALA38 TYR40 TRP52 GLY55 ILE56 SER57 TRP58 ASN59 GLY63 SER64 VAL66 VAL108 SER109 GLY110 TYR111 PHE112 PRO113 TYR114 ASP116 H: TYR31 SER33 ASN34 LYS36 TYR38 LEU52 TYR55 TRP56 THR66 GLU68 SER69 TYR107 TYR108 THR109 THR110 L: LYS133 LYS144 TYR148 ASN151 CYS152 CYS153 GLY157 GLY158 VAL159 GLU160 GLN161 PHE162 SER164 ASP165 CYS167 PRO168 LYS169 LYS170 ASP171 VAL172 LEU173 GLU174 THR175 PHE176 THR177 VAL178 LYS179 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
