Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2787 |
| PDBID: | 6RCV |
| Chains: | CB_A |
| Organism: | Plasmodium falciparum, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.58 |
| Reference: | 10.1016/j.cell.2019.05.025 |
| Antibody | |
| Antibody: | R5.011 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Reticulocyte binding protein homologue 5 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6RCV_C|Chain C, H|R5.011 heavy chain|Homo sapiens (9606) VHSEVQLVQSGSDLKKPGASVKVSCKASGYTFTSYAMNWVRQAPGQGLEWVGWINTNTGNPTYAQGFTGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCARESPNYYDSSGYYSGYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTC |
Light Chain: B
Mutation: NULL
| >6RCV_B|Chain B, G|R5.011 light chain|Homo sapiens (9606) SVTSYELTQPPSVSVAPGQTATITCGGKNIGSKSVHWYQQKPGQAPVLVVYDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVWDSSSDHRVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >6RCV_A|Chain A, F|Reticulocyte binding protein homologue 5|Plasmodium falciparum (5833) ENAIKKTKNQENQLTLLPIKSTEEEKDDIKNGKDIKKEIDNDKENIKTNNAKDHSTYIKSYLNTNVNDGLKYLFIPSHNSFIKKYSVFNQINDGMLLNEKNDVKNNEDYKNVDYKNVNFLQYHFKELSNYNIANSIDILQEKEGHLDFVIIPHYTFLDYYKHLSYNSIYHKSSTYGKCIAVDAFIKKINEAYDKVKSKCNDIKNDLIATIKKLEHPYDINNKNDDSYRYDISEEIDDKSEETDDETEEVEDSIQDTDSNHTPSNKKKNDLMNRTFKKMMDEYNTKKKKLIKCIKNHENDFNKICMDMKNYGTNLFEQLSCYNNNFCNTNGIRYHYDEYIHKLILSVKSKNLNKDLSDMTNILQQSELLLTNLNKKMGSYIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTFQKDELLKRILDMSNEYSLFITSDHLRQMLYNTFYSKEKHLNNIFHHLIYVLQMKFNDVPIKMEYFQTYKKNKPLTQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: ASN26 GLY28 SER29 LYS30 SER31 TYR48 ASP49 ASP50 SER51 ASP52 ASN65 SER66 GLY67 C: THR30 SER31 TYR32 ALA33 TRP50 ASN52 THR53 ASN54 GLU99 PRO101 ASN102 TYR103 TYR104 ASP105 SER106 SER107 TYR109 TYR110 SER111 TYR113 TYR114 A: GLU151 SER153 ASN154 TYR155 ASN156 ILE157 ALA158 ASN159 SER160 ILE161 ASP162 ILE163 ILE175 LYS301 MET304 ASP305 TYR307 ASN308 THR309 LYS311 LYS312 ILE315 LYS316 ILE318 LYS319 GLU322 LYS415 HIS419 ILE420 ARG423 LEU479 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
