Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2783 |
| PDBID: | 6R7T |
| Chains: | A_B |
| Organism: | Lama glama, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.68 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | anti MAGEB1 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Melanoma-associated antigen B1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: A
Mutation: NULL
| >6R7T_A|Chain A|anti MAGEB1 nanobody|Lama glama (9844) QVQLQESGGGLVQPGGSLRLSCAASGFTFSTYAMSWFRQAPGKGLEWVASINSSGGGIQSYADSVKGRFTISRDNAKNTLYLQMNSLEPEDTAVYYCAAAAWRVGTYDYRGQGTQVTVSSSKG |
Antigen
Chain: B
Mutation: NULL
| >6R7T_B|Chain B|Melanoma-associated antigen B1|Homo sapiens (9606) SMSTESSVKDPVAWEAGMLMHFILRKYKMREPIMKADMLKVVDEKYKEYFTEILNGASRRLELVFGLDLKEDNPSGHTYTLVSKLNLTNDGNLSNDWDFPRNGLLMPLLGVIFLKGNSATEEEIWKFMNVLGAYDGEEHLIYGEPRKFITQDLVQEKYLKYEQVPNSDPPRYQFLWGPRAYAETTKMKVLEFLAKMNGATPRDFPSHYEEALRDEEERAQVRSSVRARRRTTATTFRARSRAPFSRSSHPM |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: THR31 TYR32 ALA33 SER35 PHE37 LEU45 TRP47 SER50 ILE51 ASN52 SER53 SER54 GLY55 GLY57 ILE58 GLN59 SER60 TYR61 ALA62 ASP63 LYS66 TYR96 ALA98 ALA100 ALA101 TRP102 ARG103 VAL104 GLY105 THR106 TYR107 ASP108 ARG110 B: LEU161 VAL162 GLY164 LEU183 TRP195 PHE197 ASN200 GLY201 LEU203 MET204 LEU207 GLU254 LYS255 TYR256 PRO276 ARG277 ALA278 TYR279 ALA280 GLU281 THR282 THR283 LYS286 GLU289 PHE290 GLU313 ARG316 ALA317 GLN318 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
