Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2782 |
| PDBID: | 6R2S |
| Chains: | BA_C |
| Organism: | Homo sapiens, Plasmodium vivax Sal-1 |
| Method: | XRD |
| Resolution (Å): | 3.04 |
| Reference: | 10.1038/s41564-019-0462-1 |
| Antibody | |
| Antibody: | DB9 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium vivax Duffy receptor |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6R2S_B|Chain B|Antibody DB9 heavy chain|Homo sapiens (9606) HPLCLSLHRCPLPGPTAPRFYRLNSTMGWSCIILFLVATATGVHSEVQLQESGPGLVKPSETLSLTCTVSGGSVSSSTYYWGWVRQPPGKGLEWIGSIYYSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDGTGALDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPDPST |
Light Chain: A
Mutation: NULL
| >6R2S_A|Chain A|Antibody DB9 light chain|Homo sapiens (9606) MGWSCIILFLVATATGVHGDIVMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQRPGKAPRLLIYKASSLLSGVPSRFGGSGSGTDFTLTISSLQPDDFATYHCQHYNTYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >6R2S_C|Chain C|Duffy receptor|Plasmodium vivax (strain Salvador I) (126793) SGNTVMKNCNYKRKRRERDWDCNTKKDVCIPDRRYQLCMKELTNLVNNTDTNFHRDITFRKLYLKRKLIYDAAVEGDLLLKLNNYRYNKDFCKDIRWSLGDFGDIIMGTDMEGIGYSKVVENNLRSIFGTDEKAQQRRKQWWNESKAQIWTAMMYSVKKRLKGNFIWICKLNVAVNIEPQIYRWIREWGRDYVSELPTEVQKLKEKCDGKINYTDKKVCKVPPCQNACKSYDQWITRKKNQWDVLSNKFISVKNAEKVQTAGIVTPYDILKQELDEFNEVAFENEINKRDGAYIELCVCS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TRP51 LEU65 TYR68 LYS69 SER72 LEU73 LEU74 SER75 TYR110 ASN111 B: GLU20 VAL21 GLY45 SER51 THR52 TYR53 TYR54 TYR73 TYR74 SER75 SER77 THR78 TYR79 ARG118 GLY120 THR121 ALA123 ASP125 C: LEU404 VAL408 LYS412 ASP416 LYS418 TYR421 LYS424 TYR475 ASP476 LYS479 GLU484 ASN486 GLU487 VAL488 ALA489 GLU491 ASN492 GLU493 ASN495 ARG497 ASP498 GLY499 ALA500 ILE502 GLU503 LEU504 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
