Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2765 |
| PDBID: | 6QB4 |
| Chains: | X_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.38 |
| Reference: | 10.1107/S2059798319014116 |
| Antibody | |
| Antibody: | 55 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: X
Mutation: NULL
| >6QB4_X|Chain B[auth X]|scFv55|Homo sapiens (9606) QVTLKESGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSISSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARQVGATWAFDIWGQGTLVTVSSGGGGSGGGGSGGGGSAQSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNWYQQLPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLNAWVFGGGTKLTVLGAAAENLYFQ |
Antigen
Chain: A
Mutation: NULL
| >6QB4_A|Chain A|Induced myeloid leukemia cell differentiation protein Mcl-1|Homo sapiens (9606) GPLGSEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| X: THR28 SER30 SER31 TYR32 SER33 SER50 SER52 SER53 SER54 SER56 TYR57 TYR59 ASN74 GLN99 GLY101 ALA102 TRP104 SER166 ASN167 TRP227 ASP229 TRP234 A: LEU174 ALA205 ARG208 VAL307 LYS308 GLN309 ARG310 GLY311 TRP312 ASP313 VAL316 GLU317 PHE318 HIS320 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
