Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2758 |
| PDBID: | 6Q20 |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/Japan/305/1957(H2N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.45 |
| Reference: | 10.1126/science.aay0678 |
| Antibody | |
| Antibody: | 1G01 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | H2N2 neuraminidase |
| Antigen mutation: | No |
| Durg Target: | P06820 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6Q20_H|Chain C[auth H]|1E01 Fab IgG1 heavy chain|Homo sapiens (9606) DEVQLVESGGRVVRPGGSLRLSCAASGFTFDDYGMSWVRQPPGKGLEFVSGLNWNGDITAFTDSVKGRFTISRDNVKSSLYLQMNSLRADDTAFYYCARVRTWGDYTTGEEIINSWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCHHHHHH |
Light Chain: L
Mutation: NULL
| >6Q20_L|Chain B[auth L]|1E01 Fab kappa light chain|Homo sapiens (9606) DDIQLTQSPSFLSASVGDRVTITCRASQDISSYLAWYQQKPGNAPKLLIYAASLLQSGVPSRFSAFGSGTEFTLTISSLQPEDFATYYCQHLKSYPLFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >6Q20_A|Chain A|Neuraminidase|Influenza A virus (strain A/Japan/305/1957 H2N2) (387161) GSPSRVEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNGTIHDRIPHRTLLMNELGVPFHLGTKQVCVAWSSSSCHDGKAWLHVCVTGDDRNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIKEGKIVHISPLSGSAQHIEECSCYPRYPDVRCICRDNWKGSNRPVIDINMEDYSIDSSYVCSGLVGDTPRNDDSSSNSNCRDPNNERGNPGVKGWAFDNGDDVWMGRTISKDSRSGYETFKVIGGWSTPNSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCINRCFYVELIRGRPQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: SER31 TYR32 TYR49 ALA50 ALA51 SER52 LEU53 PHE65 GLY66 H: ASP30 ASP31 TRP52 ASN53 ILE56 ARG96 THR97 TRP98 GLY99 A: ARG118 GLU119 ILE149 ASP151 ARG152 ASP198 ARG199 SER219 GLN220 ASN221 ILE222 ARG224 GLU227 GLY244 SER245 ALA246 SER247 GLY248 ARG249 GLU276 GLU277 ARG292 ASN294 TRP295 LYS296 ASN342 ASN346 PRO347 ASP369 SER370 ARG371 TYR406 PRO431 GLN432 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
