Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2757 |
| PDBID: | 6Q1Z |
| Chains: | DC_B |
| Organism: | Influenza A virus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.45 |
| Reference: | 10.1126/science.aay0678 |
| Antibody | |
| Antibody: | 1G04 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | H7N9 neuraminidase |
| Antigen mutation: | No |
| Durg Target: | P03472 |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >6Q1Z_D|Chain D, F[auth H]|1G04 Fab IgG1 heavy chain|Homo sapiens (9606) DEVQLVESGGRVVRPGGSLRLSCAASGFTFDDYGMSWVRQAPGKGLEFVSGLNWNGDITAFTDSVKGRFTISRDNAKSSLYLQMNSLRADDTAFYYCARVRTWGEYTTREEPIHSWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCHHHHHH |
Light Chain: C
Mutation: NULL
| >6Q1Z_C|Chain C, E[auth L]|1G04 Fab kappa light chain|Homo sapiens (9606) DDIQLTQSPSFLSASVGDRVTITCRASQDISSFLAWYQQKPGNAPKVLIYAASLLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQLNSYPLFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >6Q1Z_B|Chain A, B|Neuraminidase|Influenza A virus (11320) GSPSRRNFNNLTKGLCTINSWHIYGKDNAVRIGESSDVLVTREPYVSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVHNSRVECIGWSSTSCHDGKSRMSICISGPNNNASAVVWYNRRPVAEINTWARNILRTQESECVCHNGVCPVVFTDGPATGPADTRIYYFKEGKILKWESLTGTAKHIEECSCYGERTGITCTCRDNWQGSNRPVVQIDPVAMTHTSQYICSPVLTDSPRPNDPNIGKCNDPYPGNNNNGVKGFSYLDGANTWLGRTISTASRSGYEMLKVPNALTDDRSKPIQGQTIVLNADWSGYSGSFMDYWAEGDCYRACFYVELIRGRPKEDKVWWTSNSIVSMCSSTEFLGQWNWPDGAKIEYFL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: SER30 SER31 PHE32 TYR49 ALA50 SER52 LEU53 D: ASP30 ASP31 TYR32 TRP52 ASN53 ASP55 ILE56 THR97 TRP98 GLY99 B: ARG118 GLU119 ILE149 HIS150 ASP151 ARG152 TRP178 PRO197 ASN198 ASN199 ALA219 ARG220 ASN221 ILE222 ARG224 GLU227 PRO245 ALA246 THR247 GLY248 PRO249 GLU276 GLU277 ARG292 TRP295 GLN296 PRO326 PRO342 GLY343 ASN344 ASN345 ASN346 ASN347 ALA369 SER370 ARG371 TRP403 TYR406 PRO431 LYS432 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
