Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2755 |
| PDBID: | 6Q18 |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/Beijing/262/1995(H1N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.55 |
| Reference: | 10.1073/pnas.1915620116 |
| Antibody | |
| Antibody: | H1244 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6Q18_H|Chain C[auth H]|H1244 Fab heavy chain|Homo sapiens (9606) ASQVQLQESGPGLVKPSGTLSLTCAISGGSISSSNWWTWVRQPPGKGLQWIGEIQHGGGTNYNPSLKSRATIFVDVSKNHFSLRLSSVTAADTAVYYCAKVPPYCTSASCPDDYYYHYMDVWGKGTTVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: L
Mutation: NULL
| >6Q18_L|Chain B[auth L]|H1244 Fab lambda chain|Homo sapiens (9606) ASSSELTQDPAVSVALGQTVRITCQGDSLRGYSASWYQLKPGQAPVLVIYGKNNRPSGIPDRFSGSTSGNRASLIITGTQAEDEADYYCNSRDTNGYRPVLFGGGTKLTVLGQPKGAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >6Q18_A|Chain A|Hemagglutinin|Influenza A virus (A/Beijing/262/1995(H1N1)) (518922) APLQLGNCSVAGWILGNPECESLISKESWSYIVETPNPENGTCYPGYFADYEELREQLSSVSSFERFEIFPKESSWPNHTVTGVTASCSHNGKSSFYRNLLWLTEKNGLYPNLSNSYVNNKEKEVLVLWGVHHPSNIRDQRAIYHTENAYVSVVSSHYSRRFTPEIAKRPKVRGQEGRINYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGFGSGALEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ARG96 H: GLN1 VAL2 GLY26 GLY27 SER28 SER30 SER31 SER32 ASN33 TRP34 GLN53 HIS54 GLY55 GLY56 LYS98 PRO100 PRO101 TYR102 CYS103 THR104 SER105 ALA106 SER107 CYS108 PRO109 ASP110 ASP111 TYR112 TYR113 A: TYR95 THR131 THR133 GLY134 VAL135 THR136 ALA137 SER145 TRP153 THR155 GLU156 ASN158 GLY159 LEU160 HIS183 PRO185 SER186 ASN187 ARG189 ASP190 ARG192 ALA193 ILE194 HIS196 GLU198 LYS222 GLY225 GLN226 GLU227 GLY228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
