Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2754 |
| PDBID: | 6Q0O |
| Chains: | ZB_A |
| Organism: | Influenza A virus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1073/pnas.1915620116 |
| Antibody | |
| Antibody: | H2227 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: Z
Mutation: NULL
| >6Q0O_Z|Chain C[auth Z]|H2227 Fab heavy chain|Homo sapiens (9606) QVQLQESGPGLVKPSGTLSLTCAVSGGSISSSQWWSWVRQPPGKGLEWIGEISHGVYTNYNPSLKSRVTISADKSQNQFSLNLSSVTAADTAVYYCARAPPYCSSASCPDDYYYFFLDVWGKGTTVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: B
Mutation: NULL
| >6Q0O_B|Chain B|H2227 Fab lambda chain|Homo sapiens (9606) SELTQDPAVSVALGQTVRITCQGDSLRGYYASWHQQKPGQAPVLVIYGKNNRPSGIPDRFSGSRSGNTASLTITGAQAEDEADYYCASRDSSGNHPVVFGGGTKLTVLGQPKGAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >6Q0O_A|Chain A|Hemagglutinin head domain|Influenza A virus (11320) ASAPLQLGNCSVAGWILGNPECELLISRESWSYIVEKPNPENGTCYPGHFADYEELREQLSSVSSFERFEIFPKESSWPNHTTTGVSASCSHNGESSFYKNLLWLTGKNGLYPNLSKSYANNKEKEVLVLWGVHHPPNIGDQRALYHTENAYVSVVSSHYSRKFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPRYAFALSRGFGSGLEVLF |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Z: VAL2 SER28 SER30 SER31 SER32 GLN33 HIS54 TYR57 ARG98 PRO101 TYR102 CYS103 SER104 SER105 ALA106 SER107 CYS108 PRO109 ASP110 ASP111 TYR112 A: TYR95 THR131 THR133 GLY134 VAL135 SER136 ALA137 SER145 TRP153 THR155 GLY156 ASN158 GLY159 LEU160 HIS183 PRO186 ASN187 GLY189 ASP190 ARG192 ALA193 LEU194 HIS196 GLU198 LYS222 ASP225 GLN226 GLU227 GLY228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
