Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2750 |
| PDBID: | 6Q0E |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/Beijing/262/1995(H1N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.15 |
| Reference: | 10.1073/pnas.1915620116 |
| Antibody | |
| Antibody: | Inferred-precursor-(UCA)-of-652 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6Q0E_H|Chain C[auth H]|Fab heavy chain|Homo sapiens (9606) ASQVQLQESGPGLVKPSGTLSLTCAVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGSTNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCARAPPYCSSTSCPDDYYYYYMDVWGKGTTVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: L
Mutation: NULL
| >6Q0E_L|Chain B[auth L]|Fab lambda light chain|Homo sapiens (9606) ASSSELTQDPAVSVALGQTVRITCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCNSRDSSGNHPVVFGGGTKLTVLGQPKGAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >6Q0E_A|Chain A|Hemagglutinin|Influenza A virus (A/Beijing/262/1995(H1N1)) (518922) APLQLGNCSVAGWILGNPECESLISKESWSYIVETPNPENGTCYPGYFADYEELREQLSSVSSFERFEIFPKESSWPNHTVTGVTASCSHNGKSSFYRNLLWLTEKNGLYPNLSNSYVNNKEKEVLVLWGVHHPSNIRDQRAIYHTENAYVSVVSSHYSRRFTPEIAKRPKVRGQEGRINYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGFGSGALEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR31 LYS50 ASN52 H: SER30 SER31 SER32 TYR53 HIS54 PRO101 TYR102 CYS103 SER104 SER105 THR106 SER107 CYS108 PRO109 ASP110 ASP111 TYR112 A: TYR95 THR131 THR133 GLY134 VAL135 THR136 ALA137 LYS144 SER145 TRP153 THR155 GLU156 ASN158 GLY159 HIS183 PRO185 SER186 ASN187 ARG189 ASP190 ALA193 ILE194 HIS196 LYS222 GLY225 GLN226 GLU227 GLY228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
