Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2745 |
| PDBID: | 6PZY |
| Chains: | IL_F |
| Organism: | Influenza A virus (A/environment/Shanghai/S1439/2013(H7N9)), Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.17 |
| Reference: | 10.1016/j.chom.2019.10.002 |
| Antibody | |
| Antibody: | NA-73 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | H7N9 neuraminidase |
| Antigen mutation: | No |
| Durg Target: | P03472 |
Sequence information
Antibody
Heavy Chain: I
Mutation: NULL
| >6PZY_I|Chain B[auth C], E[auth G], H, K[auth I]|NA-73 fragment antibody heavy chain|Homo sapiens (9606) QVQLEESGPGLVKPSETLSLTCTVSGYTISSGYYWGWIRQPPGKGLEWIGCNNHRGSSYYNPSLKSRVIISVDTTKNKFSLKLSSVTAADTAVYYCARDPSFWSSTSRTSPYYYGMDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: L
Mutation: NULL
| >6PZY_L|Chain C[auth D], F[auth J], I[auth K], L|NA-73 fragment antibody light chain|Homo sapiens (9606) QSVLTQPPSASGTPGQRVTISCSGSSSNIGINTVNWYQQLPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDNLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: F
Mutation: NULL
| >6PZY_F|Chain A, D[auth B], G[auth E], J[auth F]|Neuraminidase|Influenza A virus (A/environment/Shanghai/S1439/2013(H7N9)) (1347105) LKPGCNCSHSQPETTNTSQTIINNYYNETNITNIQMEERTSRNFNNLTKGLCTINSWHIYGKDNAVRIGESSDVLVTREPYVSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSSTSCHDGKSRMSICISGPNNNASAVVWYNRRPVAEINTWARNILRTQESECVCHNGVCPVVFTDGSATGPADTRIYYFKEGKILKWESLTGTAKHIEECSCYGERTGITCTCRDNWQGSNRPVIQIDPVAMTHTSQYICSPVLTDNPRPNDPNIGKCNDPYPGNNNNGVKGFSYLDGANTWLGRTISTASRSGYEMLKVPNALTDDRSKPIQGQTIVLNADWSGYSGSFMDYWAEGDCYRACFYVELIRGRPKEDKVWWTSNSIVSMCSSTEFLGQWNWPDGAKIEYFL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| I: ARG54 GLY55 SER56 SER57 TYR58 TYR59 LYS64 SER65 VAL67 ILE68 TRP99 L: ILE30 ASP93 ASN94 F: HIS150 ARG152 GLN154 PRO197 ASN198 ASN199 ALA219 ARG220 ASN221 ILE222 SER245 THR247 GLY248 PRO249 ASN294 ASN345 ASN346 ASN347 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
