Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2726 |
| PDBID: | 6PW6 |
| Chains: | H_C |
| Organism: | Human immunodeficiency virus 1, Bos taurus |
| Method: | EM |
| Resolution (Å): | 4.50 |
| Reference: | 10.1126/sciadv.aba0468 |
| Antibody | |
| Antibody: | NC-Cow1 Heavy-Chain |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 Clone BG505 SOSIP.664 gp120 |
| Antigen mutation: | No |
| Durg Target: | P00750 |
Sequence information
Antibody
Chain: H
Mutation: NULL
| >6PW6_H|Chain C[auth G], F[auth H], I|Broadly Neutralizing Antibody NC-Cow1 Heavy Chain|Bos taurus (9913) QVQLRESGPSLMKPSQTLSLTCTVSGSKSVGWVRQAPGKALQWLGSVDTSGNTDYNPGLKSRLSITKDNSKSRISLTVTGMTTEDSATYYCITAHQKTNKKECPEDYTYNPRCPQQYGWSDCDCMGDRFGGYCRQDGCSNYIHRSTYEWYVSAWGQGLLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCD |
Antigen
Chain: C
Mutation: NULL
| >6PW6_C|Chain A, D[auth C], G[auth E]|Envelope glycoprotein gp120|Human immunodeficiency virus 1 (11676) MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARAENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRRR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASP107 TYR108 ARG113 GLN117 TYR118 TRP120 ASP128 ARG129 PHE130 GLY131 GLY132 TYR133 CYS134 ARG135 GLN136 ASP137 C: ASN279 ASN280 ALA281 LYS282 ASN283 SER364 SER365 GLY366 GLY367 ASP368 GLU370 VAL371 THR372 ASN425 TRP427 GLN428 THR455 ARG456 ASP457 ARG469 PRO470 GLY471 GLY472 GLY473 ASP474 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
