Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2716 |
| PDBID: | 6PPG |
| Chains: | BA_G |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.75 |
| Reference: | 10.1080/19420862.2019.1692764 |
| Antibody | |
| Antibody: | MCAF5352A Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Afasevikumab(Phase-I) |
| Antigen | |
| Antigen: | Interleukin-17F |
| Antigen mutation: | No |
| Durg Target: | Q96PD4 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6PPG_B|Chain C[auth B], D[auth H]|Fab MCAF5352A heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSGINWSSGGIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCARDIGGFGEFYWNFGLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: A
Mutation: NULL
| >6PPG_A|Chain B[auth A], E[auth L]|Fab MCAF5352A light chain|Homo sapiens (9606) EIVLTQSPATLSLSPGERATLSCRASQSVRSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPATFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEGC |
Antigen
Chain: G
Mutation: NULL
| >6PPG_G|Chain A[auth F], F[auth G]|Interleukin-17F|Homo sapiens (9606) RKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition A: ARG30 TYR32 TYR49 ARG91 SER92 ASN93 TRP94 PRO96 B: ASP31 TYR32 ASN52 SER54 GLY56 GLY57 ILE58 GLY59 ILE100 GLY101 GLY102 PHE103 GLU105 PHE106 TYR107 TRP108 G: CYS72 LEU75 ASN79 LYS83 GLU84 ASP85 ILE86 SER87 ASN89 SER90 VAL91 PRO92 VAL125 PRO127 VAL128 ILE129 HIS130 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
