Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2715 |
| PDBID: | 6PLK |
| Chains: | IM_F |
| Organism: | Homo sapiens, Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 |
| Method: | XRD |
| Resolution (Å): | 2.30 |
| Reference: | 10.1084/jem.20191792 |
| Antibody | |
| Antibody: | ZIKV-116 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Zika virus envelope DIII |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: I
Mutation: NULL
| >6PLK_I|Chain A[auth H], D[auth I]|ZIKV-116 heavy chain|Homo sapiens (9606) EVQLVQSGRGLVRPGGSLRLSCAASGFTFSNYAMSWVRQGPGMGLEWVSTITADSDSKYYVDSVKGRFTISRDNSKDTLFLHMTSLRAEDTAVYYCAKDRLSRGVGELYDSWGQGTLVTVSSASFKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: M
Mutation: NULL
| >6PLK_M|Chain B[auth L], E[auth M]|ZIKV-116 light chain|Homo sapiens (9606) DIVMTQSPSTLSASVGDRVTITCRASQSIDVWLAWYQQKPGKAPKLLMYKTSTLQTGVPSRFSGSGSGTEFTLTISSLQTDDFATYYCQKYDSYPWTFGPGTKVEIKRTAAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: F
Mutation: NULL
| >6PLK_F|Chain C[auth E], F|Env|Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 (2043570) MRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRSGSTI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition I: ASN31 TYR32 ASP55 SER56 LYS57 TYR58 ASP95 ARG96 LEU97 SER98 ARG99 M: TRP32 TYR49 TYR91 ASP92 SER93 TYR94 TRP96 F: TYR305 SER306 LEU307 THR309 ALA310 ALA311 GLY334 THR335 ASP336 GLN350 THR351 LEU352 VAL391 GLY392 GLU393 LYS394 LYS395 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
