Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2711 |
| PDBID: | 6PHF |
| Chains: | CD_E |
| Organism: | Homo sapiens, Plasmodium falciparum |
| Method: | XRD |
| Resolution (Å): | 3.10 |
| Reference: | 10.1038/s41467-019-11980-6 |
| Antibody | |
| Antibody: | 2587 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | 25 kDa ookinete surface antigen (Pfs25) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6PHF_C|Chain A, D[auth C]|2587 Antibody Fab, Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVRKPGASVKVSCKASGYSFTSYILNWVRQATGQGLEWMGWMNPDSNNTEYAQKFQGRVTITRDTSISTVYMELSGLRSEDTAVYYCARHSFKSNTGFDYWGQGTQVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: D
Mutation: NULL
| >6PHF_D|Chain C[auth B], F[auth D]|2587 Antibody Fab, Light Chain|Homo sapiens (9606) SYELSQPPSVSVSAGQTASITCSGDKLGGKYGYWYQQRPGQSPILVIYQDSKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDISTNWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: E
Mutation: NULL
| >6PHF_E|Chain B[auth E], E[auth G]|25 kDa ookinete surface antigen|Plasmodium falciparum (5833) ETGAKVTVDTVCKRGFLIQMSGHLECKCENDLVLVNEETCEEKVLKCDEKTVNKPCGDFSKCIKIDGNPVSYACKCNLGYDMVNNVCIPNECKQVTCGNGKCILDTSNPVKTGVCSCNIGKVPNVQDQNKCSKDGETKCSLKCLKEQETCKAVDGIYKCDCKDGFIIDQESSICTGTKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition C: ILE33 TRP50 ASN52 SER55 ASN57 GLU59 PHE101 LYS102 ASN104 D: GLY26 GLY27 LYS28 TYR29 TYR31 ASP48 LYS50 ASN63 TRP88 ILE90 ASN93 E: ILE116 GLY117 LYS118 VAL119 PRO120 VAL122 SER129 LYS130 ASP131 GLY132 GLU133 THR134 LYS135 CYS136 THR146 CYS147 ALA149 TYR154 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
